2315 Title: Collagen fibrillar network in Bowman's condensation in diseased corneas
نویسندگان
چکیده
i?&bQ!k A total of 200 normal human corneas (age: 6 months 92 years) were collected among bodies intended for autopsy. Pathological comeal buttons were obtained from patients undergoing penetrating keratoplasty for keratoconus, Fuchs’ end&&xl dyamphy, postcataract endothelial dystrophy, and others. The keratocyte density was assessed using a quantitative meawem eat of the stmmal DNA-content. The endothelial cell density was counted after alitin staining. Besults: The cellularity of normal human corneas varied as timction of age. Significant differences in the cellularity of comeal dystrophies were observed when cornoared to aae-matched controls.
منابع مشابه
Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy.
PURPOSE Mouse corneas were investigated to see whether a limbal annulus of corneal collagen exists as in humans. Mice with corneas predisposed to topographical changes (the SKC strain) were also examined, to establish the size and spacing of stromal collagen fibrils and the integrity of the annulus. METHODS X-ray diffraction was used to measure collagen fibril spacing and diameter in normal (...
متن کاملAn x-ray diffraction study of corneal structure in mimecan-deficient mice.
PURPOSE Keratan sulfate proteoglycans (KSPGs) in the corneal stroma are believed to influence collagen fibrillar arrangement. This study was performed to investigate the fibrillar architecture of the corneal stroma in mice homozygous for a null mutation in the corneal KSPG, mimecan. METHODS Wild-type (n = 9) and mimecan-deficient (n = 10) mouse corneas were investigated by low-angle synchrotr...
متن کاملSecond-harmonic imaging microscopy of normal human and keratoconus cornea.
PURPOSE The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating keratoplasty were examined. A femtosecond titanium-sapphire laser with 800-...
متن کاملDevelopment of the anchoring structures of the epithelium in rabbit and human fetal corneas.
The sequence of development of the components of the corneal adhesion complex (hemidesmosomes, basal lamina and anchoring fibrils) was studied in rabbit and human fetal corneas using electron microscopy and histochemical localization of type VII (anchoring fibril) collagen. In the rabbit, basal lamina was present at 15 days gestation, followed by hemidesmosomes (HDs) and anchoring fibrils (AFs)...
متن کاملOrganization of collagen types I and V in the embryonic chicken cornea.
The distribution and organization of type I and type V collagens were studied in the embryonic chicken cornea using anti-collagen, type specific, monoclonal antibodies and immunoelectron microscopy. These studies were performed on lathyritic 17-day corneas treated at 4 degrees C or 37 degrees C. At the lower temperature, collagen fibril structure is disrupted; at the higher temperature, normal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Vision Research
دوره 35 شماره
صفحات -
تاریخ انتشار 1995